The synthesis, characterization, cytotoxicity and antitumor activity of platinum(II) complexes coordinated to O-glycoside and analogous is reported. Through the acute toxicity tests, it was possible to fit the complexes into categories according to the OECD protocol. The cis-[PtCl2(C6H14S2O2)-κ2S] complex was classified in category 3 and the cis-[PtCl2(C26H38O12S2)-κ2S] complex was classified in category 4. This result demonstrates the lower toxicity achieved by the glycoside in comparison with its analogous system. Evaluations of tumor masses extracted from mice inoculated with Ehrlich carcinoma demonstrated percent inhibition similar to cisplatin and synthesized platinum complexes. Cisplatin showed 59% inhibition, while cis-[PtCl2(C6H14S2O2)-κ2S] and cis-[PtCl2(C26H38O12S2)-κ2S] complexes presented 57% and 59%, respectively. Although the glycosidic compounds exhibit tumor activity, reported in the literature, the presence of platinum ion was shown to be determinant for antitumor action according with the compounds tested, since the glycosidic ligand presented tumor inhibition of only 38%, with a similar antitumor activity in relation to cisplatin.

The central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaining time of the animals on the Rota-rod apparatus up to 2 h. Additionally, CT at doses 100, 200 and 400 mg/ kg (i.p.) was also capable to promote an increase of latency for development of convulsions induced by pentylenetetrazole (PTZ). It was efficient in prevents the tonic convulsions induced by maximal electroshock (MES) in doses of 200 and 400 mg/kg, resulting in 30 and 40% of protection, respectively. This compound was also capable to promote an increase of latency for development of convulsions induced by picrotoxin (PIC) at 400 mg/kg. In the same way, the anticonvulsant effect of CT was affected by pretreatment with flumazenil, a selective antagonist of benzodiazepine site of GABA A receptor. These results suggest a possible CNS depressant and anticonvulsant activities.

O trabalho focaliza a escola como lócus de formação. Analisa o contexto de uma escola de sucesso da rede municipal de Campo Grande, Estado do Mato Grosso do Sul, descrevendo-o em suas características. Entre estas, destaca a gestão e o clima escolar. Para tanto, entrevista professores e gestores sobre a organização da escola, o estilo de gestão, bem como sobre os seus efeitos no trabalho do professor e no desempenho dos alunos. O exame das entrevistas permitiu construir algumas categorias que definem o ethos da instituição: o porte pequeno, o trabalho em equipe, as relações democráticas e o compromisso com os alunos. A análise destaca o profissionalismo da gestão e da sua visão prospectiva sobre a tarefa educativa, estimulando os professores a enfrentarem os desafios e compartilhando com eles as formas de superar as dificuldades. O estudo aponta a importância da rede de relações que se estabelece no contexto da escola como forma de socialização da profissão, construção da identidade docente e espaço de formação de professores a partir da prática.

This work focuses on the school as a place for teachers education. It analyses the context of a successful school in the Campo Grande municipal system, in the State of Mato Grosso do Sul. The article describes its characteristics, with emphasis on the school management and the school climate. Teachers and managers were interviewed about the school, its organization and management as well as about the way these dimensions affect their work and the students’ performance. By examining the interviews, it was possible to build up some of the categories that define the ethos of the school: the fact of it being small, team-work, democratic relationships and commitment to the students. The analysis highlights the professionalism of the management and its prospective vision of the educational task, which encourages the teachers to face up to the challenges and shares with them ways of overcoming the difficulties. It points out the importance of the network of relationships that are established within the context of the school as a way of socializing the profession, constructing a teaching identity and establishing a place were teachers can learn starting with teaching practice.

A pesquisa focaliza a construção do saber docente, buscando aprofundar a compreensão dos fatores reguladores da ação docente que atuam no sentido da manutenção da prática do professor ou no sentido da sua transformação. Para investigar as formas mediante as quais os professores aprendem e as razões que os levam a mudar ou a resistir às mudanças da prática, foi realizado um trabalho de formação, nos moldes de uma pesquisa colaborativa, envolvendo dez professoras da primeira etapa do ensino fundamental e três gestoras de uma escola selecionada dentre as que integraram a amostra de um estudo exploratório anteriormente realizado. A intervenção se realizou mediante participação prolongada dos pesquisadores na vida da escola, norteada pela convicção de que capacitação e desenvolvimento dos professores devem ser decididos pelo próprio grupo e realizados na unidade escolar, a partir das necessidades por eles expressas e visando a construção da sua autonomia. Uma análise preliminar dos registros evidencia que as mudanças são lentas, difíceis e muitas vezes os professores resistem a elas. Mas, pautada nos princípios da pesquisa colaborativa, a presente intervenção trabalhou essas dificuldades, contribuindo para a formação do professor investigador da sua prática, mediante a construção compartilhada dos saberes e da autonomia dos docentes.

The focus of our research is on how teachers construct their knowledge. We also intend to depth our understanding of the factors that regulate teachers’ action - either to maintain, either to modify their professional practice. In order to investigate the means by which teachers learn and the reasons that make them change or resist transforming their practice, we accomplished a task aiming teachers’ formation, in a manner similar to a collaborative research design, which involved part of the staff of a school chosen among others which were part of a sample of a previous exploratory study. The subjects were ten teachers of elementary teaching (first stage) and three school administrators. The intervention occurred through our constant presence in the school’s daily life, for we believe that empowerment and professional development must be a choice of teachers themselves, based on their own expressed needs toward the construction of their autonomy. A preliminary analysis of data shows that teachers sometimes resist to changes; so these are slow and difficult. Nevertheless, our intervention based on a collaborative research design enabled us to deal with these difficulties, contributing to form a kind of teacher who investigates its own practice.

Low antimycobacterial drug concentrations have been observed in tuberculosis (TB) patients under treatment. The lactulose/mannitol urinary excretion test (L/M), normally used to measure intestinal permeability, may be useful to assess drug absorption. The objective of this research was to study intestinal absorptive function and bioavailability of rifampin and isoniazid in TB patients. A cross sectional study was done with 41 patients and 28 healthy controls, using the L/M test. The bioavailabilities of rifampin (R) and isoniazid (H) were evaluated in 18 patients receiving full doses. Urinary excretion of mannitol and lactulose, measured by HPLC, was significantly lower in TB patients. The serum concentrations of the drugs were below the expected range for R (8-24 mcg/mL) or H (3-6 mcg/mL) in 16/18 patients. Analyzing the drugs individually, 12/18 patients had low serum concentrations of R, 13/18 for H and 8/18 for both drugs. We suggest that there is a decrease in the functional absorptive area of the intestine in TB patients, which would explain the reduced serum concentrations of antituberculosis drugs. There is a need for new approaches to improve drug bioavailability in TB patients.

Este estudo apresenta o perfil da atitude frente à dor em trabalhadores inseridos em atividades ocupacionais distintas com diagnóstico de LER/DORT acompanhados pelo Centro de Estudos da Saúde do Trabalhador do Estado da Bahia (CESAT/Ba). Foram entrevistados 65 trabalhadores numa amostra de conveniência. Utilizou-se como instrumento o Inventário de Atitudes Frente à Dor, na versão reduzida IAD, adaptado para língua portuguesa, contando com sete domínios ou escalas: cura médica, controle, solicitude, incapacidade, medicação, emoção e dano físico. Na análise procedeu-se a comparação das médias das escalas do IAD-breve entre as atividades ocupacionais e as variáveis socioculturais. A comparação das escalas entre as atividades ocupacionais, sexo e limitação para o trabalho revela diferenças entre as médias do domínio dano físico numa direção mais desfavorável para os industriários, sexo masculino e menor limitação para o trabalho e nos domínios emoção e controle mais favorável entre os praticantes de religião. Esses achados apontam para a possibilidade de utilização dessa abordagem para uma melhor compreensão da complexidade do fenômeno da dor crônica, assim como a necessidade de expandir o conceito da assistência e reabilitação desses trabalhadores tendo como referência um modelo de cuidado integral.

This study presents the attitude of workers in different activities (bank workers, checkout workers and industrial workers) with chronic pain related to the Repetition Strain Injures (RSI) diagnosed in an occupational outpatient clinic - Centro de Estudos da Saúde do Trabalhador (CESAT), in the State of Bahia, Brazil. Sixty five workers from a convenience sample were interviewed, using the short version of the Survey of Pain Attitude, adapted to the Portuguese language. This questionnaire contains seven domains: control, emotion, disability, physical impairment, medication, solicitude, medical cure. Student's test and Mann-Whitney test were used for comparing two and more than two means, respectively. Physical impairment was more important among male industrial workers with less limitation to work. The emotion and control domains were more favorable among people who practice a religion. These results suggest the utilization of this approach to better understand the complexity of the chronic pain among workers, and the necessity of expanding the concepts of assistance and rehabilitation in the field of Occupational Health, through an integral care model.

Este estudo apresenta o perfil da atitude frente à dor em trabalhadores inseridos em atividades ocupacionais distintas com diagnóstico de LER/DORT acompanhados pelo Centro de Estudos da Saúde do Trabalhador do Estado da Bahia (CESAT/Ba). Foram entrevistados 65 trabalhadores numa amostra de conveniência. Utilizou-se como instrumento o Inventário de Atitudes Frente à Dor, na versão reduzida IAD, adaptado para língua portuguesa, contando com sete domínios ou escalas: cura médica, controle, solicitude, incapacidade, medicação, emoção e dano físico. Na análise procedeu-se a comparação das médias das escalas do IAD-breve entre as atividades ocupacionais e as variáveis socioculturais. A comparação das escalas entre as atividades ocupacionais, sexo e limitação para o trabalho revela diferenças entre as médias do domínio dano físico numa direção mais desfavorável para os industriários, sexo masculino e menor limitação para o trabalho e nos domínios emoção e controle mais favorável entre os praticantes de religião. Esses achados apontam para a possibilidade de utilização dessa abordagem para uma melhor compreensão da complexidade do fenômeno da dor crônica, assim como a necessidade de expandir o conceito da assistência e reabilitação desses trabalhadores tendo como referência um modelo de cuidado integral.

This study presents the attitude of workers in different activities (bank workers, checkout workers and industrial workers) with chronic pain related to the Repetition Strain Injures (RSI) diagnosed in an occupational outpatient clinic - Centro de Estudos da Saúde do Trabalhador (CESAT), in the State of Bahia, Brazil. Sixty five workers from a convenience sample were interviewed, using the short version of the Survey of Pain Attitude, adapted to the Portuguese language. This questionnaire contains seven domains: control, emotion, disability, physical impairment, medication, solicitude, medical cure. Student's test and Mann-Whitney test were used for comparing two and more than two means, respectively. Physical impairment was more important among male industrial workers with less limitation to work. The emotion and control domains were more favorable among people who practice a religion. These results suggest the utilization of this approach to better understand the complexity of the chronic pain among workers, and the necessity of expanding the concepts of assistance and rehabilitation in the field of Occupational Health, through an integral care model.

Quantitative GC-FID was evaluated for analysis of methylated copaiba oils, using trans-(-)-caryophyllene or methyl copalate as external standards. Analytical curves showed good linearity and reproducibility in terms of correlation coefficients (0.9992 and 0.996, respectively) and relative standard deviation (< 3%). Quantification of sesquiterpenes and diterpenic acids were performed with each standard, separately. When compared with the integrator response normalization, the standardization was statistically similar for the case of methyl copalate, but the response of trans-(-)-caryophyllene was statistically (P < 0.05) different. This method showed to be suitable for classification and quality control of commercial samples of the oils.